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Immunohistochemical expression of endoglin (CD105) and von Willebrand factor in oral squamous cell carcinoma and its relationship with clinicopathological parameters
Conclusions The findings of this study suggest that vascular remodeling is involved in oral carcinogenesis, although there was no evidence of a significant association with clinical stage of lesions.
Source: Jornal Vascular Brasileiro - May 6, 2016 Category: Surgery Source Type: research
Inflammation-related induction of absent in melanoma 2 (AIM2) in vascular cells and atherosclerotic lesions suggests a role in vascular pathogenesis
Conclusions: ECs and VSMC are able to respond to inflammatory signals by upregulation of AIM2 expression, indicating a role of AIM2 in vascular pathogenesis.Clinical Relevance: This study revealed a prominent role of the interferon-γ–inducible double-stranded DNA sensor absent in melanoma (AIM2) in vascular inflammation. Immunohistochemical analysis suggested increased AIM2 expression in smooth muscle cells of atherosclerotic carotid lesions and the vasa vasorum of abdominal aortic aneurysms. In vitro stimulation of aortic endothelial cells and smooth muscle cells by inflammatory cytokines and double-stranded DNA drama...
Source: Journal of Vascular Surgery - June 24, 2013 Category: Surgery Authors: Maani Hakimi, Andreas Peters, Anja Becker, Dittmar Böckler, Susanne Dihlmann Tags: Basic research studies Source Type: research
The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis
Conclusion These findings indicate that the AM-RAMP2 system regulates vascular integrity, whereas RAMP2 deletion promotes vascular permeability and EndMT-like change within primary lesions and formation of pre-metastatic niches in distant organs by destabilizing the vascular structure and inducing inflammation. Vascular integrity regulated by the AM-RAMP2 system could thus be a hopeful therapeutic target for suppressing tumour metastasis.
Source: Cardiovascular Research - August 23, 2016 Category: Cardiology Authors: Tanaka, M., Koyama, T., Sakurai, T., Kamiyoshi, A., Ichikawa-Shindo, Y., Kawate, H., Liu, T., Xian, X., Imai, A., Zhai, L., Hirabayashi, K., Owa, S., Yamauchi, A., Igarashi, K., Taniguchi, S., Shindo, T. Tags: Vascular Biology Source Type: research
Re “A Multidisciplinary Approach to Oncological Resections with Vascular Surgeons Improves Patient Outcomes”
We read with interest the article by Finlay et al.1 and the accompanying editorial.2 This has highlighted an important but underappreciated aspect of vascular surgery in that we are often asked to help our oncological colleagues with major intra-abdominal resections but with little recognition or evaluation of the outcome of our practice. Unle ss we are embedded in the multidisciplinary process, this leads to the lack of an auditing process and true accountability. At the University Hospitals Birmingham unit, vascular surgeons help with iliac artery and vein dissection for melanoma, oncological resection for both intra-a...
Source: European Journal of Vascular and Endovascular Surgery - November 28, 2020 Category: Surgery Authors: Alok Tiwari, Tjun Y. Tang Tags: Letter to the Editor Source Type: research
Isolated Limb Infusion For Melanoma and Sarcoma Performed in the Endovascular Operating Room
Isolated limb infusion (ILI) is a minimally invasive technique of delivering regional chemotherapy in patients with locally advanced extremity melanoma or sarcoma who may otherwise require aggressive surgical resections or amputation. Prior reports generally describe catheter placement in the angiography suite and subsequent perfusion in the operating room (OR). We aim to demonstrate the feasibility and safety of combined angiography, catheterization and limb infusion in the endovascular OR conducted cooperatively by vascular and oncologic surgeons.
Source: Journal of Vascular Surgery - October 1, 2013 Category: Surgery Authors: Benjamin M. Jackson, Edmund K. Bartlett, Oksana A. Jackson, Ronald M. Fairman, Paul J. Foley, Douglas L. Fraker, Giorgos C. Karakousis Tags: Abstracts from the 2013 Eastern Vascular Society Annual Meeting Source Type: research
The interplay of matrix metalloproteinase-8, transforming growth factor- β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma
The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma
British Journal of Cancer 117,
1007 (26 September 2017). doi:10.1038/bjc.2017.249
Authors: Pirjo Åström, Krista Juurikka, Elin S Hadler-Olsen, Gunbjørg Svineng, Nilva K Cervigne, Ricardo D Coletta, Juha Risteli, Joonas H Kauppila, Sini Skarp, Samuel Kuttner, Ana Oteiza, Meeri Sutinen & Tuula Salo
Source: British Journal of Cancer - September 26, 2017 Category: Cancer & Oncology Authors: Pirjo Åström Krista Juurikka Elin S Hadler-Olsen Gunbj ørg Svineng Nilva K Cervigne Ricardo D Coletta Juha Risteli Joonas H Kauppila Sini Skarp Samuel Kuttner Ana Oteiza Meeri Sutinen Tuula Salo Tags: matrix metalloproteinase-8 invasion proteinase web transforming growth factor- β1 vascular endothelial growth factor-C squamous cell carcinoma tongue neoplasms Source Type: research
Influence of interleukins on prognosis of patients with oral squamous cells carcinoma
ABSTRACT Squamous cell carcinoma is a malignant neoplasm that affects the structures and tissues of the oral cavity. Interleukins (IL) synthesized from a tumor modulate a cascade reaction that may influence the prognosis of the disease. We aim to investigate in the literature whether interleukins are mediators that negatively or positively influence the prognosis of patients with oral squamous cell carcinoma. A systematic review study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) instructions. PubMed (including MedLine), Scopus, Web of Science, SciELO and Latin A...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research
Rapidly growing pulmonary ground-glass nodule caused by metastatic melanoma lacking uptake on 18F-FDG PET-CT
The objective of this systematic review was to select articles including chest X-ray or chest CT findings in patients who developed pulmonary tuberculosis following solid organ transplantation (lung, kidney, or liver). The following search terms were used: “ tuberculosis ” ; “ transplants ” ; “ transplantation ” ; “ mycobacterium ” ; and “ lung ” . The databases used in this review were PubMed and the Brazilian Biblioteca Virtual em Sa úde (Virtual Health Library). We selected articles in English, Portuguese, or Spanish, regardless of the year of publication, that met the selection criteria in their ti...
Source: Jornal Brasileiro de Pneumologia - May 21, 2018 Category: Respiratory Medicine Source Type: research
Evaluation of inter-rater reliability of subjective and objective criteria for diagnosis of lymphedema in upper and lower limbs
CONCLUSION: Manual perimetry, medical criteria, and self-report of heaviness and/or swelling exhibited better agreement for upper limbs than for lower limbs for diagnosis of lymphedema. CONTEXTO: O diagnóstico de linfedema pode ser obtido tanto de forma objetiva, por métodos de mensuração, quanto por métodos subjetivos, através da queixa do paciente. OBJETIVO: Examinar a confiabilidade entre critérios objetivos e subjetivos utilizados para o diagnóstico de linfedema e propor um ponto de corte para linfedema de membros superiores e inferiores. MÉTODOS: Foram estudados 84 pacientes submetidos à linfonodectomias par...
Source: Jornal Vascular Brasileiro - April 28, 2015 Category: Surgery Source Type: research
An aggressive case of anorectal melanoma
Publication date: July–August 2014 Source:GE Jornal Português de Gastrenterologia, Volume 21, Issue 4 Author(s): Susana Marques , Raquel Silva , Miguel Bispo , Francisco Silva , Leopoldo Matos
Source: GE Jornal Portugues de Gastrenterologia - November 1, 2014 Category: Gastroenterology Source Type: research
Melanoma maligno metastizado no estômago
Publication date: November–December 2013 Source:GE Jornal Português de Gastrenterologia, Volume 20, Issue 6 Author(s): Filipe Sousa Cardoso , David Valadas Horta
Source: GE Jornal Portugues de Gastrenterologia - December 20, 2014 Category: Gastroenterology Source Type: research
Multiple gastric metastases of malignant melanoma
Publication date: November–December 2013 Source:GE Jornal Português de Gastrenterologia, Volume 20, Issue 6 Author(s): Manuela Canhoto , Sandra Barbeiro , Bruno Arroja , Filipe Silva , Cláudia Gonçalves , Isabel Cotrim , Cristina Amado , Maria Fernanda Cunha , Martinha Henrique , Helena Vasconcelos
Source: GE Jornal Portugues de Gastrenterologia - December 20, 2014 Category: Gastroenterology Source Type: research
Melanoma maligno metastizado no est ômago
Publication date: November–December 2013 Source:GE Jornal Português de Gastrenterologia, Volume 20, Issue 6 Author(s): Filipe Sousa Cardoso, David Valadas Horta
Source: GE Jornal Portugues de Gastrenterologia - July 20, 2016 Category: Gastroenterology Source Type: research
Malignant Melanoma within a Cellular Blue Nevi Presenting as a Vascular Malformation and the Connection to Sporadic KRAS Mutations
We present a case of malignant melanoma (MM) developing within a vascular malformation showing features of cellular blue nevi. A 47-year-old male presented with acute symptoms of a temporal and zygomatic mass, which were both previously asymptomatic upon development 30 years ago. These masses were diagnosed as vascular malformations upon imaging and were treated with sclerotherapy. Embolization and surgical excision were performed 3 years later due to symptomatic growth. Final pathology reports showed MM with congenital blue nevi. We hypothesize a possible linkage to a sporadicKRAS mutation, linking both presentations of v...
Source: Case Reports in Dermatology - June 18, 2021 Category: Dermatology Source Type: research
Vascular and Neural Invasion in Oral Squamous Cell Carcinoma: A Study in an Iranian Population
CONCLUSION: The relation between neural and vascular invasion in OSCC with tumor's location was statistically significant. Lip and tongue carcinoma had shown more neurovascular invasion without relation to gender, age, and cell differentiation.PMID:37200766 | PMC:PMC10186046 | DOI:10.4103/abr.abr_220_21
Source: Cell Research - May 18, 2023 Category: Cytology Authors: Nakisa Torabinia Gholamreza Jahanshahi Vahid Eslami Forooz Keshani Source Type: research
